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Nuclear Steroid Hormone Receptor Action in the Brain |
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Pak Lab |
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Publications |
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Toni R. Pak, Ph.D |
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Assistant Professor |
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Pak TR, Chung WCJ, Hinds LR, Handa RJ (2009) Arginine vasopressin regulation in pre– and post-pubertal male rats by the androgen metabolite 3beta-diol. Am J Physiol Endocrinol Metab. 296(6):E1409-1413. Fargo KN, Pak TR, Foecking EM, Jones KJ (2008) Molecular Biology of Androgen Action. In: Hormones, Brain, and Behavior, 2nd Ed. Eds: Donald Pfaff, Arthur Arnold, Anne Etgen, and Susan Fahrbach. Academic Press (In Press). Handa RJ, Pak TR, Kudwa AE, Lund TD, Hinds LR. (2008) An alternate pathway for androgen regulation of brain function: Activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane 3beta, 17beta diol. Horm Behav. 2008 May;53(5):741-52. Pak TR, Chung WCJ, Hinds, LR, Handa RJ (2007) Estrogen receptor-β mediates DHT-induced stimulation of the arginine vasopressin promoter in neuronal cells. Endocrinology 148:3371-3382. Pak TR and Handa RJ (2007) Steroid hormone receptors and sex differences in behavior. In: Sex on the Brain: From Genes to Behavior Eds. Jill B. Becker, Karen J. Berkley, Nori Geary, Elizabeth Hampson, James Herman, and Elizabeth Young, Oxford University Press, NY. Chung WCJ, Pak TR, Suzuki S, Pouliot WA, Andersen ME, Handa RJ (2007). Distribution of estrogen receptor beta 2 splice variant in the adult female rat brain. J Comp Neurol. 505(3):249-67. Pak TR, Chung WCJ, Roberts JL, Handa RJ (2006) Ligand-independent effects of estrogen receptor beta on mouse gonadotropin releasing hormone (GnRH) promoter activity. Endocrinology 147(4):1924-1931. Chung WCJ, Pak TR, Weiser MJ, Hinds LR, Andersen ME, Handa RJ (2006) Progestin Receptor Expression in the Developing Rat Brain Depends upon Activation of Estrogen Receptor a and not Estrogen Receptor b. Brain Res. 1082(1):50-60. Handa RJ and Pak TR. (2005) Androgen Action. In: Encyclopedia of Stress 2nd ed., Ed. George Fink, Academic Press, San Diego, CA. Pak TR, Chung WCJ, Lund TD, Hinds LR, Clay CM, Handa RJ (2005) The androgen metabolite, 5a-androstane-3b, 17b-diol (3bAdiol), is a potent modulator of estrogen receptor-b1-mediated gene transcription in neuronal cells. Endocrinology 146(1):147-155. Tsai P-S, Moenter SM, Postigo HR, Majdoubi ME, Pak TR, Gill JC, Paruthiyil S, Werner S, and Weiner RI (2005) Targeted expression of a dominant negative FGF receptor in GnRH neurons reduces FGF responsiveness and the size of GnRH neuronal population. Mol Endocrinol 19:225-236. Mcmullin TS, Andersen ME, Nagahara AH, Pak T, Lund TD, Handa RJ (2004) Evidence that atrazine and diaminochlorotriazine inhibit the estrogen/progesterone induced surge of LH in female sprague-dawley rats without changing estrogen receptor action. Toxicol Sci 79(2):278-286. Pak TR, Lynch GR, and Tsai, P-S (2003) Steroidal modulation of in vitro gonadotropin secretion in prepubertal and adult male Siberian hamsters. J Exp Zool: Comp Exp Biol 298A:53-59. Pak TR, Lynch, G.R., Ziegler, D.M., Lunden, J.B., and Tsai, P.-S. (2003) Disruption of pubertal onset by exogenous testosterone and estrogen in two species of rodents. Am J Physiol Endocrinol Metab. 284:206-212. Pak TR, Lynch, GR, and Tsai, P-S (2002). Estrogen accelerates gonadal recrudescence in photo-regressed male Siberian hamsters. Endocrinology 143:4131-4134. Pak TR, Lynch GR, Tsai P.-S. (2002) Differential Alteration of the Reproductive Axis by Testosterone and Estrogen in Peripubertal and Adult Male Siberian Hamsters (Phodopus sungorus) Biol Reprod 67: 706-711. Pak TR, Lynch GR, Tsai P.-S. (2001) Testosterone and estrogen act via different pathways to inhibit puberty in the male Siberian hamster (Phodopus sungorus). Endocrinology 142:3309-3316. |
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Department of Cell and Molecular Physiology |